It is very important that your doctor check your progress at regular visitsto make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Using this medicine together with ribavirin while you are pregnant can harm your unborn baby. These medicines may also cause birth defects if the father is using it when his sexual partner becomes pregnant. If a pregnancy occurs while you are using these medicines, tell your doctor right away.
To make sure you are not pregnant, your doctor may ask you to have a pregnancy test before you start using MPI Viropack ( sofosbuvir 400 mg ). You must have a negative pregnancy test before you will be allowed to use this medicine with ribavirin. Two forms of birth control must be used during treatment and for 6 months after treatment ends. You should test for pregnancy every month while you are using this medicine, and for 6 months after your treatment ends.
Using MPI Viropack ( sofosbuvir 400 mg ) with amiodarone and another antiviral drug (eg, simeprevir) may cause bradycardia. Check with your doctor right away if you have chest pain or discomfort, lightheadedness, dizziness, or fainting, shortness of breath, slow or uneven heartbeat, or unusual tiredness.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Take MPI Viropack ( sofosbuvir 400 mg ) exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
This medicine should come with a patient information leaflet. Read and follow the information carefully. Ask your doctor if you have any questions.
To help clear up your infection completely, MPI Viropack ( sofosbuvir 400 mg ) must be taken together with peginterferon alfa and ribavirin for the full time of treatment, even if you begin to feel better after a few days. Also, it is important to keep the amount of medicine in your body at a steady level. To help keep the amount constant, MPI Viropack ( sofosbuvir 400 mg ) must be used on a regular schedule.
You may take this medicine with or without food. However, you should take it the same way each time.
The dose of MPI Viropack ( sofosbuvir 400 mg ) will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (tablets):
For hepatitis C virus infection, in combination with peginterferon alfa and ribavirin:
Adults—400 milligrams (mg) once a day.
Children—Use and dose must be determined by your doctor.
If you miss a dose of MPI Viropack ( sofosbuvir 400 mg ), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediatelyif any of the following side effects occur:
lower back or side pain
ulcers, sores, or white spots in the mouth
unusual tiredness or weakness
Changes in behavior
feeling sad or empty
loss of interest or pleasure
thoughts of killing oneself
Incidence not known
Chest pain or discomfort
lightheadedness, dizziness, or fainting
shortness of breath
slow or irregular heartbeat
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
difficulty with moving
lack or loss of strength
muscle aching or cramping
muscle pains or stiffness
rash or itching skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For MPI Viropack ( sofosbuvir 400 mg ), the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to MPI Viropack ( sofosbuvir 400 mg ) or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of MPI Viropack ( sofosbuvir 400 mg ) in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of MPI Viropack ( sofosbuvir 400 mg ) in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using MPI Viropack ( sofosbuvir 400 mg ) with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using MPI Viropack ( sofosbuvir 400 mg ) with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
St John’s Wort
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of MPI Viropack ( sofosbuvir 400 mg ). Make sure you tell your doctor if you have any other medical problems, especially:
Heart disease or
Liver disease, advanced—May increase risk for bradycardia.
Liver cirrhosis, decompensated or
Liver transplant, history of or
Kidney disease, severe—It is not known if MPI Viropack ( sofosbuvir 400 mg ) will work in patients with these conditions.