Nexavar 200mg (sorafenib) is an anticancer medicine used to treat a certain type of liver, kidney or thyroid cancer called:
- Hepatocellular carcinoma (HCC, a type of liver cancer), when it cannot be treated with surgery
- Renal cell carcinoma (RCC, a type of kidney cancer)
- Differentiated thyroid carcinoma (DTC, a type of thyroid cancer) that can no longer be treated with radioactive iodine and is progressing
Nexavar (sorafenib) has not been studied in children.
Important Safety Information
Do not take Nexavar 200mg (sorafenib) if you have a specific type of lung cancer (squamous cell) and receive carboplatin and paclitaxel or if you are allergic to sorafenib or any of the other ingredients in Nexavar (sorafenib).
Before starting Nexavar 200mg (sorafenib), tell your doctor if you have: allergies, heart problems (including a problem called “congenital long QT syndrome”) or chest pain, bleeding or bruising problems, high blood pressure, any planned surgical procedures, lung cancer or are being treated for lung cancer, kidney problems in addition to kidney cancer, or liver problems in addition to liver cancer.
Tell your doctor if you are pregnant or plan to become pregnant and if you are breast-feeding or plan to breast-feed. It is not known if Nexavar 200mg (sorafenib) passes into your breast milk. You and your doctor should decide if you will take Nexavar (sorafenib) or breast-feed. You should not do both.
Nexavar 200mg (sorafenib) may interact with certain other medicines and cause serious side effects so tell your doctor about all medicines you take including prescription and over-the-counter (OTC) medicines, vitamins, or herbal supplements.
Nexavar 200mg (sorafenib) may cause serious side effects, including:
- decreased blood flow to the heart and heart attack. Get emergency help right away and call
your doctor if you have chest pain, shortness of breath, feel lightheaded or faint, have nausea or vomiting, or you are sweating a lot.
- bleeding problems. Bleeding is a common side effect of Nexavar (sorafenib) that can be serious and
sometimes lead to death. Tell your doctor if you have any bleeding or easy bruising while taking Nexavar (sorafenib).
- high blood pressure. High blood pressure is a common side effect of Nexavar (sorafenib) and can be
serious. Your blood pressure should be checked every week during the first 6 weeks of starting therapy and then regularly, thereafter. If your blood pressure is high, it should be treated.
- a skin problem called hand-foot skin reaction. This causes redness, pain, swelling, or blisters on
the palms of your hands and soles of your feet. Your doctor may change your dose or stop treatment for a while.
- serious skin and mouth reactions. Nexavar (sorafenib) can cause serious skin and mouth reactions which
can be life-threatening. Tell your doctor if you have skin rash, blistering and peeling of the skin, blistering and peeling on the inside of your mouth.
- an opening in the wall of your stomach or intestines (perforation of the bowel). Tell your doctor
right away if you get high fever, nausea, vomiting or abdominal (stomach) pain.
- wound healing problems. If you have a surgical or dental procedure, tell your doctor you are
taking Nexavar 200mg (sorafenib). Your treatment may be stopped until after your surgery or until your wound heals.
- changes in the electrical activity of your heart called QT prolongation. QT prolongation can
cause irregular heartbeats that can be life-threatening. Your doctor may do tests during your treatment with Nexavar (sorafenib) to check the levels of potassium, magnesium, and calcium in your blood, and check the electrical activity of your heart with an ECG. Tell your doctor right away if you feel faint, lightheaded, dizzy, or feel your heart beating irregularly or fast while taking Nexavar (sorafenib).
- inflammation of your liver (drug-induced hepatitis). Nexavar (sorafenib) may cause liver problems that
-may lead to liver failure and death. Your doctor may stop your treatment with Nexavar (sorafenib) if you
develop changes in certain liver function tests. Call your doctor right away if you develop yellowing of the skin or white part of your eyes (jaundice), dark “tea-colored” urine, light-colored bowel movements (stools), worsening nausea, worsening vomiting, abdominal pain.
- birth defects or death of an unborn baby. Avoid becoming pregnant while taking Nexavar (sorafenib) and
for at least 2 weeks after stopping your treatment. Men and women should use birth control during and at least 2 weeks after Nexavar (sorafenib) therapy. Talk with your doctor about effective birth control methods. Call your doctor right away if you become pregnant.
- change in thyroid hormone levels. If you have differentiated thyroid carcinoma, you can have
changes in your thyroid hormone levels when taking Nexavar (sorafenib). Your doctor should monitor thyroid hormone levels every month and may need to increase your dose of thyroid medicine.
The most common side effects with Nexavar (sorafenib) include: diarrhea (frequent or loose bowel movements); tiredness; infection; hair thinning or patchy hair loss; rash; weight loss; loss of appetite; nausea; stomach (abdominal) pain; low blood calcium levels in people with differentiated thyroid cancer.
For important risk and use information about Nexavar (sorafenib), please see the full Prescribing Information.