Luciriboc 200mg is official Indian generic of Kisqali with active ingredient ribociclib 200 mg.
Luciriboc (ribociclib) is a kinase inhibitor indicated in combination with:
– an aromatase inhibitor for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, as initial endocrine-based therapy; or
– fulvestrant for the treatment of postmenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer, as initial endocrine-based therapy or following disease progression on endocrine therapy.
It is not known if Luciriboc (ribociclib) is safe and effective in children.
Luciriboc 200mg (ribociclib) tablets are taken orally with or without food in combination with an aromatase inhibitor or fulvestrant.
– Recommended starting dose: 600 mg orally (three 200 mg tablets) taken once daily with or without food for 21 consecutive days followed by 7 days off treatment.
– Dose interruption, reduction, and/or discontinuation may be required based on individual safety and tolerability.
Luciriboc 200mg (ribociclib) may cause serious side effects, including:
– Heart rhythm problems (QT prolongation). Luciriboc (ribociclib) can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death. Your healthcare provider should check your heart and do blood tests before and during treatment with Luciriboc (ribociclib). Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint.
– Liver problems. Luciriboc 200mg (ribociclib) can cause serious liver problems. Your healthcare provider should do blood tests to check your liver before and during treatment with Luciriboc (ribociclib). Tell your healthcare provider right away if you get any of the following signs and symptoms of liver problems, as yellowing of your skin or the whites of your eyes (jaundice); dark or brown (tea-colored) urine; feeling very tired; loss of appetite; pain on the upper right side of your stomach area (abdomen); bleeding or bruising more easily than normal.
– Low white blood cell counts (neutropenia). Low white blood cell counts are very common when taking Luciriboc (ribociclib) and may result in infections that may be severe. Your healthcare provider should check your white blood cell counts before and during treatment with Luciriboc (ribociclib). Tell your healthcare provider right away if you have signs and symptoms of low white blood cell counts or infections such as fever and chills.
– Your healthcare provider may tell you to decrease your dose, temporarily stop or completely stop taking Luciriboc (ribociclib) if you develop certain serious side effects during treatment with Luciriboc (ribociclib).
Most common adverse reactions (incidence ≥ 20%) are neutropenia, nausea, infections, fatigue, diarrhea, leukopenia, vomiting, alopecia, headache, constipation, rash and cough.