Keytruda (pembrolizumab): Side and adverse effects

24 Jul

Keytruda (pembrolizumab): Side and adverse effects

KeytrudaDuring treatment with keytruda 100mg (pembrolizumab), side effects can occur and should be treated as early as possible. In clinical trials with Keytruda (pembrolizumab), some patients stopped treatment due to side effects. Tell your doctor if you have any side effect that bothers you or that does not go away.

 

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SERIOUS SIDE EFFECTS

 

keytruda 100mg (pembrolizumab) is a medicine that may treat certain cancers by working with your immune system. Keytruda (pembrolizumab) can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended.

 

Call or see your doctor right away if you develop any symptoms of the following problems or these symptoms get worse:

 

Lung problems (pneumonitis)

Shortness of breath

Chest pain

New or worse cough

 

Intestinal problems (colitis) that can lead to tears or holes in your intestine

Diarrhea or more bowel movements than usual

Stools that are black, tarry, sticky, or have blood or mucus

Severe stomach-area (abdomen) pain or tenderness

 

Liver problems (hepatitis)

Yellowing of your skin or the whites of your eyes

Nausea or vomiting

Pain on the right side of your stomach area (abdomen)

Dark urine

Feeling less hungry than usual

Bleeding or bruising more easily than normal

 

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Hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas)

Rapid heart beat

Weight loss or weight gain

Increased sweating

Feeling more hungry or thirsty

Urinating more often than usual

Hair loss

Feeling cold

Constipation

Your voice gets deeper

Muscle aches

Dizziness or fainting

Headaches that will not go away or unusual headache

 

Kidney problems, including nephritis and kidney failure

Change in the amount or color of your urine

 

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Skin problems

Rash

Itching

Blisters, peeling, or skin sores

Painful sores or ulcers in your mouth or in your nose, throat, or genital area

 

Problems in other organs

Changes in eyesight

Severe or persistent muscle or joint pains

Severe muscle weakness

Low red blood cells (anemia)

Swollen lymph nodes, rash or tender lumps on skin, cough, shortness of breath, vision changes, or eye pain (sarcoidosis)

Confusion, fever, muscle weakness, balance problems, nausea, vomiting, stiff neck, memory problems, or seizures (encephalitis)

Shortness of breath, irregular heartbeat, feeling tired, or chest pain (myocarditis)

 

Infusion (IV) reactions that can sometimes be severe or life‑threatening

Chills or shaking

Shortness of breath or wheezing

Itching or rash

Flushing

Dizziness

Fever

Feeling like passing out

Rejection of a transplanted organ. People who have had an organ transplant may have an increased risk of organ transplant rejection. Your doctor should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.

 

Complications, including graft-versus-host-disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with Keytruda (pembrolizumab). Your doctor will monitor you for the following signs and symptoms: skin rash, liver inflammation, stomach-area (abdominal) pain, and diarrhea.

 

Getting medical treatment right away may help keep these problems from becoming more serious. Your doctor will check you for these problems during treatment with Keytruda (pembrolizumab). Your doctor may treat you with corticosteroid or hormone replacement medicines. Your doctor may also need to delay or completely stop treatment with Keytruda (pembrolizumab), if you have severe side effects.

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COMMON SIDE EFFECTS

Common side effects of Keytruda (pembrolizumab) when used alone include: feeling tired, pain, including pain in muscles, bones or joints and stomach-area (abdominal) pain, decreased appetite, itching, diarrhea, nausea, rash, fever, cough, shortness of breath, and constipation.

 

In children, feeling tired, vomiting and stomach-area (abdominal) pain, and increased levels of liver enzymes and decreased levels of salt (sodium) in the blood are more common than in adults.

 

These are not all the possible side effects of Keytruda (pembrolizumab). For more information, ask your doctor or pharmacist. Tell your doctor if you have any side effect that bothers you or that does not go away.

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